Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969377 | 0.86 | IDO1 (0.53) | IDO1TAAR1ABCB1GAAMAPT | |
| SCHEMBL9350071 | 0.80 | TAAR1 (0.56) | IDO1TAAR1GAAMAPTALDH1A1 | |
| SCHEMBL28384840 | 0.79 | IDO1 (0.66) | IDO1TAAR1ABCB1GAAMAPT | |
| SCHEMBL26654 | 0.78 | IDO1 (0.69) | IDO1TAAR1ABCB1GAAMAPT | |
| Hydrochloric Acid SCHEMBL9350890 | 0.78 | TAAR1 (0.55) | IDO1TAAR1GAAMAPTALDH1A1 | |
| SCHEMBL7965699 | 0.77 | IDO1 (0.52) | IDO1TAAR1MAPTALDH1A1TACR1 | |
| SCHEMBL7955676 | 0.77 | IDO1 (0.52) | IDO1TAAR1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL7964819 | 0.77 | IDO1 (0.52) | IDO1TAAR1GAAALDH1A1MEN1 | |
| SCHEMBL7965694 | 0.77 | IDO1 (0.52) | IDO1TAAR1MAPTALDH1A1TACR1 | |
| SCHEMBL7955669 | 0.77 | IDO1 (0.52) | IDO1TAAR1MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |