Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.40 |
| ▸ | CCND1 | P24385 | 12/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 12/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.40 |
| ▸ | CDK2 | P24941 | 12/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961772 | 0.93 | TDP1 (0.40) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7963176 | 0.88 | CRHR1 (0.46) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7963257 | 0.85 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Acetic Acid SCHEMBL8113498 | 0.84 | CDK4 (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7968457 | 0.84 | CRHR1 (0.48) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7968810 | 0.83 | CDK4 (0.39) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8123969 | 0.82 | CDK4 (0.53) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5611280 | 0.81 | CRHR1 (0.56) | TDP1CRHR1 | |
| SCHEMBL7967906 | 0.81 | CRHR1 (0.43) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7966305 | 0.79 | CCNE2 (0.50) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |