Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | FPR3 | P25089 | 2/20 | 0.40 |
| ▸ | TSPO | P30536 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611280 | 0.93 | CRHR1 (0.56) | CRHR1TDP1FPR3TSPOTMEM97 | |
| SCHEMBL7967906 | 0.86 | CRHR1 (0.43) | CRHR1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL9018497 | 0.85 | CRHR1 (0.45) | CRHR1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL7961772 | 0.84 | TDP1 (0.40) | CRHR1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL7965770 | 0.84 | CDK4 (0.40) | CRHR1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL5599902 | 0.83 | CDK4 (0.52) | CRHR1CDK4CCND1CCNE2CCNE1 | |
| Acetic Acid SCHEMBL7953282 | 0.81 | CDK4 (0.50) | CRHR1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL5600331 | 0.78 | CDK4 (0.53) | CRHR1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL5600433 | 0.76 | CRHR1 (0.57) | CRHR1TDP1CDK4CCND1CCNE2 | |
| SCHEMBL8121281 | 0.76 | CDK4 (0.53) | CRHR1TDP1CDK4CCND1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |