Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963830 | 0.91 | DHODH (0.36) | IDO1HSP90AA1TDP2ALDH1A1KDM4E | |
| SCHEMBL7967474 | 0.90 | HSP90AA1 (0.35) | IDO1HSP90AA1TDP2HSP90B1DHODH | |
| SCHEMBL7961242 | 0.90 | IDO1 (0.34) | IDO1HSP90AA1TDP2KDM4EMEN1 | |
| SCHEMBL7952437 | 0.88 | DHODH (0.34) | TDP2ALDH1A1MAPTDHODHPOLB | |
| SCHEMBL7952832 | 0.87 | HCRTR1 (0.34) | IDO1HSP90AA1TDP2ALDH1A1HSP90B1 | |
| SCHEMBL7952188 | 0.87 | IDO1 (0.35) | IDO1HSP90AA1TDP2HSP90B1KDM4E | |
| SCHEMBL8328807 | 0.87 | DHODH (0.39) | IDO1KDM4EMAPTDHODHPOLB | |
| SCHEMBL7965560 | 0.86 | HPGD (0.32) | ALDH1A1DHODHHPGDLMNASMN1; SMN2 | |
| SCHEMBL7961927 | 0.83 | IDO1 (0.35) | IDO1HSP90AA1TDP2ALDH1A1HSP90B1 | |
| SCHEMBL7964306 | 0.82 | MAPT (0.32) | MAPTDHODHPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |