Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237364 | 0.84 | MAPK14 (0.47) | MAPK14ACHEDRD2SLC6A4GRM4 | |
| SCHEMBL15487431 | 0.82 | MAPK14 (0.49) | MAPK14ACHEDRD2SLC6A4GRM4 | |
| SCHEMBL461287 | 0.82 | ACHE (0.61) | ACHEDRD2SLC6A4SCDHTR2A | |
| SCHEMBL470707 | 0.82 | MAPK14 (0.52) | MAPK14ACHEDRD2SLC6A4GRM4 | |
| SCHEMBL3523366 | 0.82 | MAPK14 (0.47) | MAPK14ACHEDRD2SLC6A4GRM4 | |
| SCHEMBL1545681 | 0.82 | MAPK14 (0.47) | MAPK14ACHEDRD2SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL531052 | 0.81 | ACHE (0.60) | ACHEDRD2SLC6A4SCDHTR2A | |
| Hydrochloric Acid SCHEMBL15486032 | 0.81 | MAPK14 (0.48) | MAPK14ACHEDRD2SLC6A4GRM4 | |
| Hydrochloric Acid SCHEMBL607480 | 0.81 | MAPK14 (0.46) | MAPK14ACHEHTR2AHTR7 | |
| SCHEMBL13201170 | 0.79 | HTR2C (0.48) | MAPK14ACHEDRD2SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |