Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MITF | O75030 | 1/20 | 0.70 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966311 | 1.00 | KDM4E (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL1206716 | 0.95 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL1206715 | 0.95 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| Hydrochloric Acid SCHEMBL11768179 | 0.93 | KDM4E (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL7336575 | 0.89 | ALDH1A1 (0.72) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL7336570 | 0.89 | ALDH1A1 (0.72) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL17321122 | 0.89 | KDM4E (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL17311318 | 0.88 | KDM4E (0.57) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL17311317 | 0.88 | KDM4E (0.57) | KDM4EALDH1A1HPGDSMN1; SMN2MITF | |
| SCHEMBL7969685 | 0.88 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277502-B1 | ORGANOSILICON POLYMERS; LIQUID CRYSALS | ROLIC AG (CH) | 2001-08-21 | — | — | US | disclosed |
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |