Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966474 | 0.96 | PKM (0.42) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7966470 | 0.96 | PKM (0.42) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7951623 | 0.87 | KCNH2 (0.37) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7951625 | 0.87 | KCNH2 (0.37) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7966583 | 0.85 | KCNH2 (0.49) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7960320 | 0.85 | KCNH2 (0.49) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7960147 | 0.84 | HTT (0.51) | PKMKCNH2PDE4AELANEKDM4E | |
| SCHEMBL7960497 | 0.83 | CNR1 (0.51) | PKMKCNH2PDE4AELANECNR1 | |
| SCHEMBL7960214 | 0.83 | KCNH2 (0.49) | PKMKCNH2PDE4AELANEIKBKE | |
| SCHEMBL7168115 | 0.82 | KCNH2 (0.58) | KCNH2PDE4AIKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |