Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966583 | 1.00 | KCNH2 (0.49) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960214 | 0.91 | KCNH2 (0.49) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7966470 | 0.89 | PKM (0.42) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7966474 | 0.89 | PKM (0.42) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7954732 | 0.89 | PDE4A (0.62) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960372 | 0.89 | PDE4A (0.62) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7963094 | 0.89 | PDE4A (0.62) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7962912 | 0.85 | HTT (0.47) | KCNH2PDE4APKMELANE | |
| SCHEMBL7962911 | 0.85 | HTT (0.47) | KCNH2PDE4APKMELANE | |
| SCHEMBL7966418 | 0.85 | PKM (0.44) | KCNH2PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |