Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PTAFR | P25105 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966683 | 1.00 | KCNJ1 (0.37) | KCNJ1PPARGNCOA2NCOA1NCOA3 | |
| SCHEMBL7966288 | 0.89 | CYP11B1 (0.39) | KCNJ1PPARGNCOA2NCOA1NCOA3 | |
| SCHEMBL7966286 | 0.89 | CYP11B1 (0.39) | KCNJ1PPARGNCOA2NCOA1NCOA3 | |
| SCHEMBL7979898 | 0.87 | PGK1 (0.39) | PPARGNCOA2NCOA1NCOA3CYP11B1 | |
| SCHEMBL7979900 | 0.87 | PGK1 (0.39) | PPARGNCOA2NCOA1NCOA3CYP11B1 | |
| SCHEMBL7978428 | 0.82 | CYP3A4 (0.38) | CYP3A4PTAFR | |
| SCHEMBL7978426 | 0.82 | CYP3A4 (0.38) | CYP3A4PTAFR | |
| SCHEMBL7980330 | 0.81 | CYP11B1 (0.47) | KCNJ1CYP11B1CYP11B2 | |
| SCHEMBL7980327 | 0.81 | CYP11B1 (0.47) | KCNJ1CYP11B1CYP11B2 | |
| SCHEMBL8119036 | 0.81 | MEN1 (0.39) | KCNJ1CYP11B1CYP11B2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |