Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 17/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 17/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980330 | 1.00 | CYP11B1 (0.47) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL7966286 | 0.93 | CYP11B1 (0.39) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL7966288 | 0.93 | CYP11B1 (0.39) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL7976679 | 0.91 | CYP19A1 (0.42) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL7976683 | 0.91 | CYP19A1 (0.42) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL8020645 | 0.91 | CYP19A1 (0.42) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL7982720 | 0.90 | PTAFR (0.38) | KCNJ1 | |
| SCHEMBL7982723 | 0.90 | PTAFR (0.38) | KCNJ1 | |
| SCHEMBL7982493 | 0.89 | CYP11B2 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL7982496 | 0.89 | CYP11B2 (0.39) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |