Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969774 | 0.91 | MAP3K7 (0.38) | TLR9TLR7 | |
| SCHEMBL7966770 | 0.90 | IRAK4 (0.34) | TP53GAAMEN1KMT2AIRAK4 | |
| SCHEMBL7967359 | 0.85 | AVPR2 (0.35) | IRAK4 | |
| SCHEMBL7966544 | 0.80 | BRD4 (0.37) | BRD4TP53GAA | |
| SCHEMBL7484853 | 0.80 | BRD4 (0.37) | BRD4TP53GAAMEN1KMT2A | |
| SCHEMBL7476090 | 0.79 | BRD4 (0.41) | BRD4TP53GAAMEN1KMT2A | |
| SCHEMBL7341146 | 0.78 | BRD4 (0.49) | BRD4TP53GAAMEN1KMT2A | |
| SCHEMBL7344138 | 0.77 | GAA (0.42) | BRD4TP53GAA | |
| SCHEMBL7340419 | 0.76 | TP53 (0.51) | BRD4TP53GAAMEN1KMT2A | |
| SCHEMBL7345937 | 0.76 | PDE4A (0.43) | BRD4TP53GAATLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |