Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30864224 | 0.94 | MEN1 (0.60) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4257667 | 0.89 | ALDH1A1 (0.72) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL22095571 | 0.84 | MEN1 (0.89) | MEN1KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL977581 | 0.84 | MEN1 (0.69) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL7965075 | 0.82 | NPSR1 (0.77) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL4883742 | 0.82 | MAPT (0.52) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL28344092 | 0.82 | ALDH1A1 (0.64) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL22095086 | 0.82 | AURKA (0.85) | MEN1KMT2AALDH1A1RAB9AMAPT | |
| SCHEMBL7956598 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL22095047 | 0.80 | LMNA (0.85) | MEN1KMT2AALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306883-B1 | NOVEL PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND AND INHIBITING CYTOKINES BY A COMPOUND OF FORMULA (I) AND THE TREATMENT OF CYTOKINES MEDIATED DISEASES, | SMITHKLINE BEECHAM CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-5998425-A | CYTOKINE ANTAGONIST; ANTIARTHRITIC AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-07 | — | — | US | disclosed |