Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 14/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 12/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7965301 | 0.99 | ADRA1A (0.56) | ADRA1AADRA1DADRA1BOPRM1CCR1 | |
| SCHEMBL7966984 | 0.96 | ADRA1A (0.56) | ADRA1AADRA1DADRA1BOPRM1CCR1 | |
| SCHEMBL7662404 | 0.86 | OPRM1 (0.50) | ADRA1AADRA1DADRA1BOPRM1 | |
| Hydrochloric Acid SCHEMBL7664062 | 0.85 | OPRM1 (0.49) | ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL7668749 | 0.84 | OPRM1 (0.48) | ADRA1AADRA1DADRA1BOPRM1 | |
| Hydrochloric Acid SCHEMBL7967744 | 0.83 | ADRA1A (0.54) | ADRA1AADRA1DADRA1BOPRM1CCR1 | |
| Hydrochloric Acid SCHEMBL7702085 | 0.83 | OPRM1 (0.47) | ADRA1AADRA1DADRA1BOPRM1 | |
| Hydrochloric Acid SCHEMBL7664127 | 0.83 | OPRM1 (0.47) | ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL6887168 | 0.82 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL6198369 | 0.81 | OPRM1 (0.71) | ADRA1AADRA1DADRA1BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274583-B1 | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. | 2001-08-14 | — | — | US | disclosed |
| US-5977115-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0833637-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0833637-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040136-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |