Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.40 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.40 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.40 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.40 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.40 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.40 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994810 | 0.92 | CHRM1 (0.46) | HRH1CHRM1PAK1HTR2AHTR3E | |
| Maleic Acid SCHEMBL7669315 | 0.90 | CHRM1 (0.43) | HRH1CHRM1PAK1HTR2AHTR3E | |
| Maleic Acid SCHEMBL7666985 | 0.90 | CHRM1 (0.42) | HRH1CHRM1PAK1HTR2AHTR3E | |
| SCHEMBL6993572 | 0.85 | CHRM1 (0.46) | HRH1CHRM1PAK1HTR2AHTR3E | |
| SCHEMBL6998924 | 0.85 | CHRM1 (0.38) | HRH1CHRM1PAK1HTR2AHTR3E | |
| SCHEMBL6998153 | 0.84 | CHRM1 (0.45) | HRH1CHRM1PAK1HTR2AHTR3E | |
| SCHEMBL6996709 | 0.83 | CHRM1 (0.46) | HRH1CHRM1PAK1HTR2AHTR3E | |
| Maleic Acid SCHEMBL7656194 | 0.83 | CHRM1 (0.49) | HRH1CHRM1PAK1HTR2AHTR3E | |
| SCHEMBL6990220 | 0.81 | CHRM1 (0.49) | HRH1CHRM1PAK1HTR2AHTR3E | |
| Maleic Acid SCHEMBL7665213 | 0.81 | HTR2A (0.34) | HRH1CHRM1HTR2AHTR3EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271225-B1 | PSYCHOLOGICAL DISORDERS | WELFIDE CORPORATION (JP) | 2001-08-07 | — | — | US | disclosed |