Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.50 |
| ▸ | CCND1 | P24385 | 17/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 14/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.49 |
| ▸ | CDK2 | P24941 | 14/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965911 | 0.80 | CRHR1 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8126327 | 0.76 | CDK4 (0.44) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965323 | 0.76 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7968943 | 0.75 | CCNE2 (0.60) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7964689 | 0.71 | CDK4 (0.56) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7953100 | 0.70 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5611027 | 0.69 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7044979 | 0.69 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7044978 | 0.69 | CDK4 (0.55) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8113413 | 0.68 | CDK4 (0.58) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |