Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.56 |
| ▸ | CCND1 | P24385 | 15/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 11/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.43 |
| ▸ | CDK2 | P24941 | 11/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.43 |
| ▸ | CDK1 | P06493 | 5/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968943 | 0.84 | CCNE2 (0.60) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7953100 | 0.84 | CDK4 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965323 | 0.82 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7961654 | 0.79 | CRHR1 (0.54) | CDK4CCND1CRHR1HPGD | |
| SCHEMBL7953211 | 0.74 | CDK4 (0.56) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7965911 | 0.72 | CRHR1 (0.63) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5826757 | 0.72 | CDK4 (0.54) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7969123 | 0.71 | CDK4 (0.67) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8126327 | 0.71 | CDK4 (0.44) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7967892 | 0.71 | CDK4 (0.50) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |