Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.44 |
| ▸ | CCR2 | P41597 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964799 | 0.87 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| SCHEMBL7971326 | 0.87 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| SCHEMBL7970730 | 0.87 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| Hydrochloric Acid SCHEMBL7967251 | 0.86 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| Hydrochloric Acid SCHEMBL6964411 | 0.86 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| Hydrochloric Acid SCHEMBL7968249 | 0.86 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| SCHEMBL6966134 | 0.84 | ADRA1D (0.45) | ADRA1AADRA1DADRA1BCCR2KCNH2 | |
| SCHEMBL7082968 | 0.79 | ADRA1A (0.60) | ADRA1AADRA1DADRA1B | |
| SCHEMBL7842959 | 0.79 | ADRA1D (0.44) | ADRA1AADRA1DADRA1BCCR2 | |
| SCHEMBL6964803 | 0.75 | ADRA1A (0.40) | ADRA1AADRA1DADRA1BSLC6A9DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |