Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 10/20 | 0.69 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27532541 | 0.90 | PLA2G2A (0.56) | PLA2G2APLA2G10LMNAARRAD52 | |
| SCHEMBL7964627 | 0.81 | PLA2G2A (1.00) | PLA2G2A | |
| SCHEMBL7952555 | 0.81 | PLA2G2A (0.70) | PLA2G2APLA2G10LMNAAR | |
| SCHEMBL3385771 | 0.80 | PLA2G2A (0.69) | PLA2G2ALMNAAR | |
| SCHEMBL3389070 | 0.76 | LMNA (0.74) | PLA2G2ALMNAAR | |
| SCHEMBL7963220 | 0.75 | PLA2G10 (1.00) | PLA2G2APLA2G10 | |
| SCHEMBL1149940 | 0.73 | KMT2A (0.70) | PLA2G2ALMNA | |
| SCHEMBL11467535 | 0.72 | PLA2G2A (0.56) | PLA2G2ALMNA | |
| SCHEMBL11109847 | 0.72 | PLA2G2A (0.48) | PLA2G2ALMNAAR | |
| SCHEMBL27363619 | 0.71 | PLA2G2A (0.81) | PLA2G2ALMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |