Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.81 |
| ▸ | MMP13 | P45452 | 3/20 | 0.81 |
| ▸ | CTSD | P07339 | 4/20 | 0.80 |
| ▸ | IDH1 | O75874 | 2/20 | 0.68 |
| ▸ | GSK3B | P49841 | 3/20 | 0.67 |
| ▸ | MMP3 | P08254 | 2/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | MGAM | O43451 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SI | P14410 | 1/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.58 |
| ▸ | NAT1 | P18440 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968336 | 1.00 | ADAMTS5 (0.81) | ADAMTS5MMP13CTSDIDH1GSK3B | |
| SCHEMBL1249082 | 0.90 | ADAMTS5 (1.00) | ADAMTS5MMP13CTSDIDH1GSK3B | |
| SCHEMBL1249080 | 0.90 | ADAMTS5 (1.00) | ADAMTS5MMP13CTSDIDH1GSK3B | |
| SCHEMBL12891797 | 0.90 | ADAMTS5 (1.00) | ADAMTS5MMP13CTSDIDH1GSK3B | |
| SCHEMBL7968997 | 0.89 | CTSD (1.00) | ADAMTS5MMP13CTSDMMP3 | |
| SCHEMBL7969001 | 0.89 | CTSD (1.00) | ADAMTS5MMP13CTSDMMP3 | |
| SCHEMBL7969195 | 0.89 | CTSD (1.00) | ADAMTS5MMP13CTSDMMP3 | |
| SCHEMBL7969199 | 0.89 | CTSD (1.00) | ADAMTS5MMP13CTSDMMP3 | |
| SCHEMBL7968993 | 0.89 | CTSD (1.00) | ADAMTS5MMP13CTSDMMP3 | |
| SCHEMBL20976496 | 0.84 | ADAMTS5 (0.77) | ADAMTS5MMP13CTSDIDH1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |