SCHEMBL7968342

SCHEMBL7968342

NCC(N)COCc1ccc(Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.50
CHRNA4 P43681 1/20 0.50
IDO1 P14902 2/20 0.48
AGXT P21549 2/20 0.48
SLC6A4 P31645 1/20 0.48
HTT P42858 2/20 0.47
USP2 O75604 1/20 0.47
GAA P10253 1/20 0.47
MAPK1 P28482 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TACR1 P25103 5/20 0.46
MAOB P27338 4/20 0.44
KMT2A Q03164 1/20 0.44
HPGD P15428 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A3 Q01959 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7968337 1.00 CHRNB2 (0.50) CHRNB2CHRNA4IDO1AGXTSLC6A4
SCHEMBL9066224 0.84 HTT (0.51) IDO1AGXTSLC6A4HTTUSP2
SCHEMBL9066226 0.84 HTT (0.51) IDO1AGXTSLC6A4HTTUSP2
SCHEMBL9066177 0.84 HTT (0.51) IDO1AGXTSLC6A4HTTUSP2
SCHEMBL7967707 0.82 TACR1 (0.59) IDO1AGXTTACR1
SCHEMBL7965700 0.82 TACR1 (0.59) IDO1AGXTTACR1
SCHEMBL2781643 0.82 TACR1 (0.59) IDO1AGXTTACR1
SCHEMBL7964945 0.81 IDO1 (0.48) IDO1AGXTTACR1MAOB
SCHEMBL7971279 0.81 IDO1 (0.48) IDO1TACR1MAOB
SCHEMBL7955762 0.81 IDO1 (0.48) IDO1AGXTTACR1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6274715-B1 SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY ABBOTT LABORATORIES 2001-08-14 US disclosed
EP-0961776-A1 TRICYCLIC ERYTHROMYCIN DERIVATIVES Abbott Laboratories (US) 1999-12-08 EP disclosed
WO-1998030574-A1 TRICYCLIC ERYTHROMYCIN DERIVATIVES ABBOTT LABORATORIES (US) 1998-07-16 WO disclosed