Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 16/20 | 0.67 |
| ▸ | CYSLTR1 | Q9Y271 | 16/20 | 0.67 |
| ▸ | CTSD | P07339 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971603 | 0.86 | CTSD (0.65) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9172468 | 0.84 | LMNA (0.68) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9173547 | 0.84 | GRM2 (0.68) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9173157 | 0.84 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9175712 | 0.83 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL8560511 | 0.83 | CYSLTR2 (0.63) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL22800103 | 0.83 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9180015 | 0.82 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9176107 | 0.82 | CYSLTR2 (0.61) | CYSLTR2CYSLTR1CTSD | |
| SCHEMBL9179128 | 0.81 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |