Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756822 | 0.86 | SLC6A4 (0.57) | SLC6A4DRD2KDM4EHTR1ASLC6A2 | |
| SCHEMBL10268348 | 0.77 | SLC6A4 (0.69) | SLC6A4DRD2KDM4ESLC6A2SLC6A3 | |
| SCHEMBL4457596 | 0.76 | SLC6A4 (0.48) | SLC6A4DRD2KDM4ESLC6A2SLC6A3 | |
| SCHEMBL7955713 | 0.76 | GAA (0.46) | SLC6A4DRD2HTR1AHRH3 | |
| SCHEMBL5758570 | 0.76 | GAA (0.46) | SLC6A4DRD2HTR1AHRH3 | |
| SCHEMBL7955710 | 0.76 | GAA (0.46) | SLC6A4DRD2HTR1AHRH3 | |
| SCHEMBL13698231 | 0.74 | SLC6A4 (0.61) | SLC6A4DRD2KDM4EHTR1ASLC6A2 | |
| SCHEMBL5405317 | 0.73 | SLC6A4 (0.59) | SLC6A4DRD2KDM4ESLC6A2SLC6A3 | |
| SCHEMBL5756712 | 0.73 | SLC6A4 (0.46) | SLC6A4DRD2KDM4ESLC6A2SLC6A3 | |
| SCHEMBL5757587 | 0.73 | SLC6A4 (0.46) | SLC6A4DRD2KDM4ESLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |