Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7971982 | 0.92 | MAP3K7 (0.37) | MAP3K7MAPTIRAK4LMNAAVPR2 | |
| SCHEMBL7975598 | 0.92 | HDAC8 (0.44) | HDAC8MEN1KMT2ARAB9AMAP3K7 | |
| Hydrochloric Acid SCHEMBL7955818 | 0.91 | HDAC8 (0.44) | HDAC8MEN1KMT2ARAB9AMAP3K7 | |
| SCHEMBL7975461 | 0.90 | MAP3K7 (0.37) | MAP3K7MAPTIRAK4ABCB1AVPR2 | |
| SCHEMBL7473083 | 0.89 | MAP3K7 (0.37) | MAP3K7IRAK4ABCB1AVPR2AVPR1A | |
| SCHEMBL7474290 | 0.89 | MAP3K7 (0.37) | MAP3K7IRAK4ABCB1AVPR2AVPR1A | |
| SCHEMBL7597522 | 0.89 | MAP3K7 (0.36) | MAP3K7IRAK4ABCB1AVPR2AVPR1A | |
| Hydrochloric Acid SCHEMBL7480957 | 0.89 | MAP3K7 (0.43) | HDAC8MAP3K7IRAK4 | |
| SCHEMBL7975517 | 0.88 | MAP3K7 (0.36) | HDAC8MAP3K7IRAK4ABCB1AVPR2 | |
| SCHEMBL7961822 | 0.88 | MAP3K7 (0.35) | MAP3K7IRAK4AVPR2AVPR1AAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |