Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.67 |
| ▸ | MMP3 | P08254 | 1/20 | 0.67 |
| ▸ | CTSD | P07339 | 6/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968641 | 1.00 | MMP13 (0.67) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7975149 | 0.92 | MMP13 (0.72) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7975146 | 0.92 | MMP13 (0.72) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7968931 | 0.90 | MMP3 (0.69) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7968927 | 0.90 | MMP3 (0.69) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL4053583 | 0.89 | MMP3 (0.71) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL4049839 | 0.89 | MMP3 (0.71) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7968119 | 0.86 | MMP3 (0.72) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7968122 | 0.86 | MMP3 (0.72) | MMP13MMP3CTSDADAMTS5POLB | |
| SCHEMBL7971922 | 0.84 | MMP3 (0.64) | MMP13MMP3CTSDPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |