Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968684 | 0.88 | PARP1 (0.43) | NPC1RAB9AMAPTKDM4EGFER | |
| SCHEMBL2708884 | 0.82 | MPO (0.54) | NPC1RAB9AMAPTKDM4EGFER | |
| SCHEMBL12209610 | 0.82 | ALDH1A1 (0.57) | NPC1RAB9AMAPTKDM4EGFER | |
| SCHEMBL14447469 | 0.82 | MAPT (0.74) | NPC1RAB9AMAPTKDM4EGFER | |
| Hydrochloric Acid SCHEMBL25241510 | 0.81 | MPO (0.53) | NPC1RAB9AMAPTKDM4EGFER | |
| Hydrochloric Acid SCHEMBL3707758 | 0.81 | MPO (0.53) | NPC1RAB9AMAPTKDM4EGFER | |
| Hydrochloric Acid SCHEMBL30456349 | 0.81 | MPO (0.53) | NPC1RAB9AMAPTKDM4EGFER | |
| SCHEMBL2711634 | 0.79 | NPY5R (0.56) | NPC1RAB9AMAPTKDM4EGFER | |
| SCHEMBL22639961 | 0.78 | POLB (0.54) | NPC1RAB9AMAPTKDM4EGFER | |
| Hydrochloric Acid SCHEMBL3707760 | 0.78 | NPY5R (0.55) | NPC1RAB9AMAPTKDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |