Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.57 |
| ▸ | CTSD | P07339 | 6/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968939 | 1.00 | MMP3 (0.62) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL7971526 | 0.87 | MMP3 (0.71) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL7971523 | 0.87 | MMP3 (0.71) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL4056382 | 0.84 | HPGD (0.82) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL4056380 | 0.84 | HPGD (0.82) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL4055509 | 0.83 | MMP13 (0.76) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL4055508 | 0.83 | MMP13 (0.76) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL4059997 | 0.81 | MMP13 (0.66) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL4059996 | 0.81 | MMP13 (0.66) | MMP3MMP13PTGS2HPGDCSNK2A2 | |
| SCHEMBL2066016 | 0.79 | PTP4A3 (0.70) | GSK3BCISD1NAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |