Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964785 | 0.98 | LMNA (0.40) | PRMT5WDR77LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7200725 | 0.90 | OPRL1 (0.41) | LMNAALDH1A1SMN1; SMN2LTA4HOPRL1 | |
| SCHEMBL7969555 | 0.88 | OPRL1 (0.45) | PRMT5WDR77LMNAALDH1A1LTA4H | |
| SCHEMBL7962985 | 0.87 | LTA4H (0.39) | LMNAALDH1A1SMN1; SMN2LTA4HOPRL1 | |
| SCHEMBL7966386 | 0.86 | LTA4H (0.38) | LMNAALDH1A1LTA4HOPRL1DRD3 | |
| SCHEMBL7969481 | 0.86 | LTA4H (0.38) | LMNAALDH1A1LTA4HOPRL1DRD2 | |
| SCHEMBL7969312 | 0.86 | LTA4H (0.45) | PRMT5WDR77LMNAALDH1A1LTA4H | |
| SCHEMBL7966953 | 0.86 | OPRL1 (0.39) | LMNAALDH1A1LTA4HOPRL1MEN1 | |
| SCHEMBL7953348 | 0.86 | MEN1 (0.47) | LMNAALDH1A1LTA4HOPRL1DRD2 | |
| SCHEMBL7953456 | 0.86 | OPRL1 (0.39) | PRMT5WDR77LMNAALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |