Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594888 | 0.83 | KMT2A (0.45) | KMT2AMAPK1USP2SMN1; SMN2MEN1 | |
| SCHEMBL7021331 | 0.83 | AVPR2 (0.41) | KMT2AMAPK1USP2SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7965581 | 0.82 | KMT2A (0.44) | KMT2AMAPK1USP2SMN1; SMN2MEN1 | |
| SCHEMBL7538522 | 0.82 | BRPF1 (0.42) | KMT2AMAPK1SMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL7534660 | 0.82 | MEN1 (0.35) | KMT2AMEN1BRPF1MAPTTP53 | |
| SCHEMBL7014299 | 0.79 | PDE4A (0.48) | SMN1; SMN2TSHR | |
| SCHEMBL7598283 | 0.79 | IRAK4 (0.38) | KMT2AMEN1L3MBTL1BRPF1MAPT | |
| SCHEMBL7023856 | 0.78 | AVPR1A (0.38) | USP2SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7015520 | 0.78 | PRMT5 (0.39) | SMN1; SMN2BRPF1MAPTALDH1A1KDM4E | |
| SCHEMBL7025753 | 0.78 | AVPR2 (0.39) | KMT2AMAPK1USP2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |