Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538522 | 0.89 | BRPF1 (0.42) | BRPF1KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL7534090 | 0.83 | RXFP1 (0.33) | IRAK4RXFP1BRPF1BRD4KMT2A | |
| SCHEMBL7593381 | 0.80 | BRD4 (0.43) | IRAK4RXFP1BRPF1BRD4KMT2A | |
| Hydrochloric Acid SCHEMBL7598923 | 0.80 | BRD4 (0.42) | IRAK4RXFP1BRPF1BRD4KMT2A | |
| SCHEMBL7969233 | 0.79 | KMT2A (0.42) | BRPF1BRD4KMT2ARAB9AMEN1 | |
| SCHEMBL7534660 | 0.75 | MEN1 (0.35) | IRAK4RXFP1BRPF1BRD4KMT2A | |
| SCHEMBL7965105 | 0.74 | L3MBTL1 (0.46) | KMT2ARAB9ALMNAL3MBTL1MAPT | |
| SCHEMBL7954361 | 0.73 | L3MBTL1 (0.45) | KMT2ARAB9ALMNAL3MBTL1GAA | |
| SCHEMBL7599052 | 0.70 | HTT (0.49) | IRAK4BRPF1KMT2AMEN1LMNA | |
| SCHEMBL7973753 | 0.70 | KMT2A (0.46) | RXFP1BRPF1BRD4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |