Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.57 |
| ▸ | RAF1 | P04049 | 3/20 | 0.57 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | ARAF | P10398 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969356 | 1.00 | KMT2A (0.57) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL1394615 | 0.88 | LRRK2 (0.60) | KMT2AMAPTMEN1POLBPLK4 | |
| SCHEMBL1394617 | 0.88 | LRRK2 (0.60) | KMT2AMAPTMEN1POLBPLK4 | |
| SCHEMBL7979342 | 0.87 | DHFR (0.77) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL7979340 | 0.87 | DHFR (0.77) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL4726411 | 0.83 | RAF1 (0.79) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL1394784 | 0.83 | RAF1 (0.79) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL5369680 | 0.80 | ERBB2 (0.56) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL5369976 | 0.78 | MAPT (0.62) | KMT2AMAPTMEN1POLBRAF1 | |
| SCHEMBL6690796 | 0.78 | RAF1 (0.76) | KMT2AMAPTMEN1POLBRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |