Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | GAA | P10253 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | SNCA | P37840 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979342 | 1.00 | DHFR (0.77) | DHFRMAPTKMT2AMEN1GAA | |
| SCHEMBL1394810 | 0.89 | APP (0.64) | DHFRMAPTAPPSNCARAF1 | |
| SCHEMBL1394809 | 0.89 | APP (0.64) | DHFRMAPTAPPSNCARAF1 | |
| SCHEMBL7969356 | 0.87 | KMT2A (0.57) | DHFRMAPTKMT2AMEN1GAA | |
| SCHEMBL1394615 | 0.87 | LRRK2 (0.60) | DHFRMAPTKMT2AMEN1GAA | |
| SCHEMBL1394617 | 0.87 | LRRK2 (0.60) | DHFRMAPTKMT2AMEN1GAA | |
| SCHEMBL7969352 | 0.87 | KMT2A (0.57) | DHFRMAPTKMT2AMEN1GAA | |
| SCHEMBL7979219 | 0.82 | DHFR (0.84) | DHFRMAPTKMT2AALDH1A1TDP1 | |
| SCHEMBL1395377 | 0.82 | DHFR (0.84) | DHFRKMT2AMEN1GAARAF1 | |
| SCHEMBL5082716 | 0.82 | DHFR (0.84) | DHFRMAPTKMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |