Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.74 |
| ▸ | DRD4 | P21917 | 5/20 | 0.74 |
| ▸ | DRD3 | P35462 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7959100 | 0.99 | DRD2 (0.72) | DRD2DRD4DRD3ALDH1A1TSHR | |
| SCHEMBL7498064 | 0.85 | DRD4 (1.00) | DRD2DRD4DRD3ALDH1A1TSHR | |
| SCHEMBL7958862 | 0.82 | HTT (0.64) | DRD2DRD4DRD3ALDH1A1KDM4E | |
| SCHEMBL7972133 | 0.80 | MEN1 (0.63) | DRD2DRD4DRD3ALDH1A1TSHR | |
| Maleic Acid SCHEMBL7991621 | 0.80 | DRD4 (0.83) | DRD2DRD4DRD3ALDH1A1TSHR | |
| Fumaric Acid SCHEMBL7991623 | 0.80 | DRD4 (0.83) | DRD2DRD4DRD3ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL7968793 | 0.79 | MEN1 (0.62) | DRD2DRD4DRD3ALDH1A1TSHR | |
| SCHEMBL3585542 | 0.78 | ALDH1A1 (1.00) | DRD2DRD4DRD3ALDH1A1TSHR | |
| SCHEMBL7508845 | 0.76 | DRD2 (1.00) | DRD2DRD4DRD3ALDH1A1KDM4E | |
| SCHEMBL8872544 | 0.76 | ALDH1A1 (0.78) | DRD2DRD4DRD3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281359-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2001-08-28 | — | — | US | disclosed |
| US-6221871-B1 | TREATING SCHIZOPHRENIA, DEPRESSION OR PARKINSON'S DISEASE | NEUROGEN CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-5912350-A | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands | NEUROGEN CORPORATION (US) | 1999-06-15 | — | — | US | disclosed |
| US-5594141-A | ANTIPSYCHOTIC AND ANTIDEPRESSANT AGENTS; PARKINSON'S DISEASE | NEUROGEN CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |