Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797445 | 0.86 | TP53 (0.40) | GRM5MAPTTP53POLBMEN1 | |
| SCHEMBL15477231 | 0.86 | S1PR1 (0.50) | S1PR1GRM5ALOX5APMAPTTP53 | |
| SCHEMBL796497 | 0.82 | NPC1 (0.42) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL796477 | 0.74 | TP53 (0.49) | S1PR1MAPTTP53POLBMEN1 | |
| SCHEMBL796837 | 0.71 | CDK9 (0.46) | GRM5MAPTTP53MEN1KMT2A | |
| SCHEMBL795790 | 0.71 | AURKA (0.41) | S1PR1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL795637 | 0.70 | MAPT (0.43) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL796445 | 0.68 | S1PR1 (0.48) | S1PR1GRM5ALOX5APMAPTTP53 | |
| SCHEMBL807929 | 0.68 | ACHE (0.40) | S1PR1 | |
| SCHEMBL795351 | 0.68 | BRAF (0.40) | GRM5MAPTTP53POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-A1 | TRIAZINE-OXADIAZOLES | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |