Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28834350 | 0.78 | MEN1 (0.58) | MEN1KMT2AHTR2CNPC1RAB9A | |
| SCHEMBL7956610 | 0.74 | HTR2C (0.50) | MEN1KMT2AHTR2CCYP1A2CYP2C19 | |
| SCHEMBL20767872 | 0.73 | SCN4A (0.48) | MEN1KMT2AHTR2CCYP1A2CYP2C19 | |
| SCHEMBL7967239 | 0.73 | MEN1 (0.52) | MEN1KMT2AHTR2CNPC1RAB9A | |
| SCHEMBL2710382 | 0.72 | KMT2A (1.00) | MEN1KMT2ANPC1RAB9ACYP1A2 | |
| SCHEMBL7965987 | 0.70 | HTR2C (0.49) | MEN1KMT2AHTR2CCYP1A2CYP2C19 | |
| SCHEMBL2708511 | 0.70 | NPC1 (0.64) | MEN1KMT2AHTR2CNPC1RAB9A | |
| SCHEMBL24820021 | 0.70 | HDAC3 (0.44) | MEN1KMT2ANPC1RAB9ACYP1A2 | |
| SCHEMBL2966860 | 0.69 | HTR2C (0.57) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL7956612 | 0.69 | PARP1 (0.57) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |