Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | C1R | P00736 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23411785 | 0.82 | MPO (0.46) | SLC6A2SLC6A4HTR1ASLC6A3MPO | |
| SCHEMBL20135544 | 0.79 | HTR2C (0.46) | HTR2CCYP1A2SLC6A2SLC6A4HTR1A | |
| SCHEMBL204714 | 0.74 | PARP1 (0.51) | KDM4EALDH1A1 | |
| SCHEMBL2961557 | 0.73 | HTR2C (0.49) | HTR2CCYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL7966615 | 0.73 | LMNA (0.46) | HTR2CSLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL373400 | 0.72 | MPO (0.54) | MPOALDH1A1MEN1KMT2APOLB | |
| SCHEMBL7956610 | 0.71 | HTR2C (0.50) | HTR2CCYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL2709039 | 0.70 | MPO (0.59) | HTR2CMPOCASP6ALDH1A1MEN1 | |
| SCHEMBL7969690 | 0.70 | MEN1 (0.56) | HTR2CCYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL22382316 | 0.68 | C1R (0.41) | CYP1A2CYP2C19KDM4EALDH1A1C1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |