Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969766 | 1.00 | ALOX5 (0.47) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7972931 | 1.00 | ALOX5 (0.47) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7973077 | 0.89 | ALOX5 (0.40) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7973079 | 0.89 | ALOX5 (0.40) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7972773 | 0.89 | ALOX5 (0.40) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7972771 | 0.89 | ALOX5 (0.40) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7972772 | 0.89 | ALOX5 (0.40) | ALOX5ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7959777 | 0.83 | ALOX5 (0.64) | ALOX5ALDH1A1MAP1LC3BHTR2AHTR2C | |
| SCHEMBL7972876 | 0.83 | ALOX5 (0.47) | ALOX5ALDH1A1HTR2CHTR2BNPC1 | |
| SCHEMBL7973196 | 0.83 | ALOX5 (0.47) | ALOX5ALDH1A1MAP1LC3BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |