Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973077 | 1.00 | ALOX5 (0.40) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7972773 | 1.00 | ALOX5 (0.40) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7972772 | 1.00 | ALOX5 (0.40) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7973079 | 1.00 | ALOX5 (0.40) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7972931 | 0.89 | ALOX5 (0.47) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7969766 | 0.89 | ALOX5 (0.47) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7969764 | 0.89 | ALOX5 (0.47) | ALOX5CYP2C9ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7959762 | 0.85 | ALOX5 (0.53) | ALOX5HRH3AKR1C3AKR1C1NPC1 | |
| SCHEMBL7959765 | 0.85 | ALOX5 (0.53) | ALOX5HRH3AKR1C3AKR1C1NPC1 | |
| SCHEMBL7971120 | 0.85 | ALOX5 (0.53) | ALOX5HRH3AKR1C3AKR1C1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |