Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972776 | 1.00 | ALOX5 (0.48) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL7969793 | 1.00 | ALOX5 (0.48) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL9198851 | 0.90 | HTR2C (0.43) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL9198858 | 0.90 | HTR2C (0.43) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL7973201 | 0.90 | HTR2C (0.43) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL7973210 | 0.90 | HTR2C (0.43) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL7973205 | 0.90 | HTR2C (0.43) | ALOX5HTR2CKDM4EGAATDP1 | |
| SCHEMBL7975762 | 0.86 | ALOX5 (0.44) | ALOX5TDP1ALDH1A1MAPTKIF11 | |
| SCHEMBL7975858 | 0.86 | ALOX5 (0.44) | ALOX5TDP1ALDH1A1MAPTKIF11 | |
| SCHEMBL7975766 | 0.86 | ALOX5 (0.44) | ALOX5TDP1ALDH1A1MAPTKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |