SCHEMBL7969942

SCHEMBL7969942

COc1cc(C(=O)N(C)c2ccc(C)cc2OCCC(=C=O)N2CCN(C)CC2)ccc1NC(=O)c1cccc2[nH]c(CNC(=O)OC(C)(C)C)nc12

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.35
BRD4 O60885 2/20 0.35
PARP1 P09874 2/20 0.35
MAP3K7 O43318 4/20 0.34
ABL1 P00519 1/20 0.33
SRC P12931 1/20 0.33
IRAK4 Q9NWZ3 2/20 0.32
PTGES O14684 1/20 0.30
TSHR P16473 1/20 0.30
MAPK10 P53779 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961971 0.92 AVPR2 (0.37) JAK2BRD4PARP1MAP3K7ABL1
SCHEMBL7967361 0.91 BRD4 (0.36) JAK2BRD4PARP1MAP3K7ABL1
SCHEMBL7969777 0.88 JAK2 (0.39) JAK2BRD4PARP1MAP3K7ABL1
SCHEMBL7954153 0.87 MAP3K7 (0.37) BRD4PARP1MAP3K7IRAK4
SCHEMBL7596836 0.87 MAP3K7 (0.36) BRD4PARP1MAP3K7IRAK4PTGES
Hydrochloric Acid SCHEMBL7966670 0.87 MAP3K7 (0.37) BRD4PARP1MAP3K7IRAK4
SCHEMBL7964818 0.87 PDE3B (0.35) BRD4PARP1
Hydrochloric Acid SCHEMBL7975724 0.86 PTGES (0.36) MAP3K7PTGES
SCHEMBL7966353 0.86 TSHR (0.38) BRD4PARP1IRAK4PTGESTSHR
SCHEMBL7482373 0.86 BRD4 (0.34) BRD4PARP1IRAK4PTGESTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed