Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970295 | 1.00 | LMNA (0.45) | LMNATHRBUSP2MPOHTR2B | |
| SCHEMBL7970303 | 1.00 | LMNA (0.45) | LMNATHRBUSP2MPOHTR2B | |
| SCHEMBL23411587 | 0.82 | MPO (0.48) | MPOTP53MAPTPOLBMEN1 | |
| SCHEMBL27415075 | 0.82 | EPHX1 (0.46) | LMNATHRBUSP2MPOHTR2B | |
| SCHEMBL23442931 | 0.82 | MPO (0.48) | MPOTP53MAPTPOLBMEN1 | |
| SCHEMBL29891833 | 0.82 | MPO (0.48) | MPOTP53MAPTPOLBMEN1 | |
| SCHEMBL373400 | 0.80 | MPO (0.54) | LMNATHRBUSP2MPOHTR2B | |
| SCHEMBL26862272 | 0.78 | LMNA (0.60) | LMNATHRBUSP2HTR2BEPHX1 | |
| SCHEMBL26295449 | 0.77 | LMNA (0.53) | LMNATHRBUSP2HTR2BTP53 | |
| SCHEMBL5566584 | 0.77 | LMNA (0.45) | LMNATHRBUSP2HTR2BEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |