Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492787 | 0.72 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7968533 | 0.72 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492654 | 0.72 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492720 | 0.71 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1493028 | 0.71 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492897 | 0.71 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492691 | 0.70 | WNT3A (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492824 | 0.70 | EPHX1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492789 | 0.70 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1493037 | 0.69 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |