Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.46 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834934 | 0.92 | CNR1 (0.44) | CNR1TRPV1GPR119NPC1RAB9A | |
| SCHEMBL1198787 | 0.85 | PDE10A (0.56) | GPR119DRD4DRD3DRD2GRM1 | |
| SCHEMBL26962767 | 0.83 | NPC1 (0.46) | GPR119NPC1RAB9AGRM1GRM5 | |
| SCHEMBL29858208 | 0.83 | NPC1 (0.46) | GPR119NPC1RAB9AGRM1GRM5 | |
| SCHEMBL8369432 | 0.82 | NPC1 (0.48) | TRPV1NPC1RAB9ADRD4DRD3 | |
| SCHEMBL23290770 | 0.82 | GRM1 (0.46) | CNR1GPR119GRM1GRM5PDK4 | |
| SCHEMBL7970683 | 0.80 | PDK4 (0.51) | CNR1GPR119GRM1GRM5PDK4 | |
| SCHEMBL26962691 | 0.79 | LMNA (0.49) | GPR119NPC1PDK4JAK1PDE10A | |
| SCHEMBL29858299 | 0.79 | LMNA (0.49) | GPR119NPC1PDK4JAK1PDE10A | |
| SCHEMBL30513848 | 0.79 | GRM1 (0.44) | CNR1TRPV1GPR119GRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |