Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.48 |
| ▸ | GRM5 | P41594 | 9/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848328 | 0.92 | PDK4 (0.44) | PDK4GRM1GRM5GPR119NAMPT | |
| SCHEMBL1198787 | 0.84 | PDE10A (0.56) | PDK4GRM1GRM5GPR119NAMPT | |
| SCHEMBL7826168 | 0.82 | DRD4 (0.41) | GPR119JAK1 | |
| SCHEMBL23290770 | 0.81 | GRM1 (0.46) | PDK4GRM1GRM5GPR119JAK1 | |
| SCHEMBL7970682 | 0.80 | CNR1 (0.49) | PDK4GRM1GRM5GPR119JAK1 | |
| SCHEMBL31169315 | 0.79 | GPR119 (0.52) | PDK4GRM1GRM5GPR119NAMPT | |
| SCHEMBL30135250 | 0.78 | PDK4 (0.68) | PDK4GRM1GRM5NAMPTDGAT2 | |
| SCHEMBL2882861 | 0.78 | PDK4 (0.68) | PDK4GRM1GRM5NAMPTDGAT2 | |
| SCHEMBL30308912 | 0.77 | GRM1 (0.64) | PDK4GRM1GRM5GPR119NAMPT | |
| SCHEMBL23216670 | 0.77 | PDK4 (0.58) | PDK4GRM1GRM5NAMPTDGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |