Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 11/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | FNTA | P49354 | 6/20 | 0.49 |
| ▸ | FNTB | P49356 | 6/20 | 0.49 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936681 | 0.79 | CYP11B1 (0.62) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8801601 | 0.77 | MAPT (0.50) | CYP19A1 | |
| SCHEMBL7083825 | 0.76 | CYP11B1 (0.76) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8677989 | 0.75 | CYP11B1 (0.70) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7505069 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7507201 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7480675 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL6925307 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL10588300 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL3630524 | 0.74 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |