Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027088 | 0.84 | MAPT (0.51) | MAPTCYP2A6LOXL2CYP19A1BCHE | |
| SCHEMBL5421553 | 0.80 | MAPT (0.58) | MAPTCYP2A6LOXL2CYP19A1BCHE | |
| SCHEMBL17227603 | 0.78 | CYP2A6 (0.57) | MAPTCYP2A6LOXL2CYP19A1BCHE | |
| SCHEMBL4681715 | 0.78 | CA1 (0.48) | MAPTALDH1A1CA1CA2CA9 | |
| SCHEMBL3677944 | 0.77 | MAPT (0.47) | MAPTCYP2A6LOXL2CYP19A1BCHE | |
| SCHEMBL28377908 | 0.77 | L3MBTL1 (0.44) | MAPTBCHEACHEALDH1A1TSHR | |
| SCHEMBL27549032 | 0.77 | YAP1 (0.41) | MAPTBCHEACHEALDH1A1CA1 | |
| SCHEMBL7971072 | 0.77 | CYP11B1 (0.58) | CYP19A1 | |
| SCHEMBL7831391 | 0.77 | BRS3 (0.41) | MAPTCYP2A6LOXL2BCHEACHE | |
| SCHEMBL354454 | 0.76 | KMT2A (0.57) | ALDH1A1CA1CA2CA9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745086-A4 | TRICYCLIC SPIROPIPERIDINES | MERCK & CO INC (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0745086-A1 | TRICYCLIC SPIROPIPERIDINES | MERCK & CO. INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995022548-A1 | TRICYCLIC SPIROPIPERIDINES | MERCK & CO., INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| US-5439914-A | Antiarrhythmic agents; treating impaired cardiac pump funcations | MERCK & CO., INC. (US) | 1995-08-08 | — | — | US | disclosed |