Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971274 | 1.00 | TAAR1 (0.42) | TAAR1MAOAPTGS1MTNR1AMTNR1B | |
| SCHEMBL7971270 | 1.00 | TAAR1 (0.42) | TAAR1MAOAPTGS1MTNR1AMTNR1B | |
| SCHEMBL7956112 | 0.82 | TAAR1 (0.45) | TAAR1MAOAPTGS1LMNASLC6A2 | |
| SCHEMBL7956107 | 0.82 | TAAR1 (0.45) | TAAR1MAOAPTGS1LMNASLC6A2 | |
| SCHEMBL7956104 | 0.82 | TAAR1 (0.45) | TAAR1MAOAPTGS1LMNASLC6A2 | |
| SCHEMBL7160865 | 0.79 | KDM4E (0.41) | TAAR1MAOAPTGS1MTNR1AMTNR1B | |
| SCHEMBL27839110 | 0.78 | MTNR1A (0.45) | MTNR1AMTNR1BLMNASLC6A3 | |
| SCHEMBL1453272 | 0.78 | CA4 (0.48) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| SCHEMBL3160069 | 0.77 | MTNR1A (0.50) | TAAR1MAOAPTGS1MTNR1AMTNR1B | |
| SCHEMBL5729049 | 0.77 | MTNR1A (0.50) | TAAR1MAOAPTGS1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |