Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707315 | 0.88 | CTNNB1 (0.53) | CTNNB1KMT2APARP10PARP3LMNA | |
| SCHEMBL5974724 | 0.83 | LTA4H (0.48) | CTNNB1KMT2ALMNAGAACYP2C9 | |
| 4-Hydroxybenzaldehyde SCHEMBL28715730 | 0.79 | CTNNB1 (0.51) | CTNNB1KMT2ALMNAGAACYP2C9 | |
| Cyclopropane SCHEMBL5972973 | 0.79 | LTA4H (0.44) | CTNNB1KMT2ALMNAGAAKDM4E | |
| SCHEMBL708142 | 0.78 | ALDH1A1 (0.54) | CTNNB1KMT2ALMNACYP2C9RAB9A | |
| SCHEMBL25960695 | 0.77 | TTR (0.64) | CTNNB1KMT2APARP10PARP3LMNA | |
| SCHEMBL2562259 | 0.77 | CTNNB1 (0.70) | CTNNB1KMT2APARP10PARP3LMNA | |
| SCHEMBL13599494 | 0.77 | CTNNB1 (0.47) | CTNNB1KMT2APARP10PARP3LMNA | |
| SCHEMBL8311249 | 0.77 | TTR (0.58) | KMT2APARP10PARP3LMNAGAA | |
| SCHEMBL9664968 | 0.77 | CTNNB1 (0.47) | CTNNB1KMT2APARP10PARP3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |