Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976222 | 0.91 | CHEK2 (0.44) | PRKCZCHEK2 | |
| SCHEMBL10139990 | 0.90 | ATR (0.40) | CDK2CHEK2ATRRHEBF9 | |
| SCHEMBL7975900 | 0.90 | CHEK2 (0.40) | CDK2CHEK2BRD4ATRRHEB | |
| SCHEMBL7973155 | 0.89 | F9 (0.39) | NPBWR1CHEK2BRD4ATRF9 | |
| SCHEMBL7972135 | 0.88 | PDE10A (0.37) | CDK2CHEK2F9F10F11 | |
| SCHEMBL7970581 | 0.88 | F9 (0.40) | NPBWR1CHEK2BRD4ATRF9 | |
| SCHEMBL7970061 | 0.87 | GUSB (0.39) | CHEK2PDE10A | |
| SCHEMBL7960814 | 0.87 | NPC1 (0.39) | BRD4RHEBPDE10A | |
| SCHEMBL7970587 | 0.87 | TOP1 (0.34) | CHEK2ATRF9F10F11 | |
| SCHEMBL7971397 | 0.87 | ALDH1A1 (0.39) | NPBWR1CDK2PRKCZF9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |