Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 12/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | F9 | P00740 | 3/20 | 0.40 |
| ▸ | F11 | P03951 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139992 | 0.92 | CHEK2 (0.50) | CHEK2 | |
| SCHEMBL10140002 | 0.92 | F10 (0.49) | F10F9F11F7F2 | |
| SCHEMBL7973410 | 0.81 | PTGDR2 (0.36) | NOS3NOS1HDAC3HDAC1HDAC8 | |
| SCHEMBL7972318 | 0.80 | CHEK2 (0.56) | CHEK2F10F9F11F7 | |
| SCHEMBL10139912 | 0.80 | CHEK2 (0.48) | CHEK2 | |
| SCHEMBL7971019 | 0.77 | F10 (0.43) | CHEK2F10F9F11F7 | |
| SCHEMBL7960639 | 0.76 | F10 (0.38) | F10F9F11NOS3NOS1 | |
| SCHEMBL10139864 | 0.76 | CHEK2 (0.55) | CHEK2 | |
| SCHEMBL7966356 | 0.76 | CHEK2 (0.55) | CHEK2 | |
| SCHEMBL10139924 | 0.76 | PTGDR2 (0.37) | F10F9F11HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |