Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | PAM | P19021 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21185428 | 0.87 | MEN1 (0.48) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1119176 | 0.86 | CES2 (0.59) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL21769296 | 0.84 | MAPT (0.53) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23052609 | 0.83 | MEN1 (0.50) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4755209 | 0.83 | CES2 (0.55) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16578400 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL14934928 | 0.80 | ALDH1A1 (0.61) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7868721 | 0.79 | CES2 (0.50) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11317095 | 0.78 | MEN1 (0.49) | CES2CES1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11317097 | 0.78 | MEN1 (0.49) | CES2CES1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |